Artistic work of astute construction (6)
I believe the answer is:
statue
'artistic work' is the definition.
(I've seen this before)
'astute construction' is the wordplay.
'construction' is an anagram indicator (answer constructed from certain letters).
'astute' anagrammed gives 'STATUE'.
'of' acts as a link.
(Other definitions for statue that I've seen before include "See figure" , "Sculpture depicting a person" , "Solid representation of the human form" , "Noble's rank or dignity" , "Life sculpture" .)