Artist's fierce struggle with endless difficulty (6)
I believe the answer is:
warhol
'artist's' is the definition.
(Andy Warhol)
'fierce struggle with endless difficulty' is the wordplay.
'fierce struggle' becomes 'war' (warring is a kind of struggling. I am not sure about the 'fierce' bit.).
'with' says to put letters next to each other.
'endless' means to remove the last letter.
'difficulty' becomes 'hole' (hole can mean a difficult situation).
'hole' with its last letter taken off is 'hol'.
'war'+'hol'='WARHOL'
Can you help me to learn more?
(Other definitions for warhol that I've seen before include "Modern artist" , "- Fisher (B. Potter)" , "20th century artist" , "Andy -, twentieth century US artist" , "Andy ......., pop art icon of the 1960s" .)