As those with large corporation? (5)
I believe the answer is:
obese
'with large corporation?' is the definition.
(corporation can humorously mean body fat)
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for obese that I've seen before include "Excessively fat" , "Very substantial" , "indecently large)" , "Morbidly overweight" , "Unhealthily fat and overweight" .)