Ascetic at last departing for Ruhr location (5)
I believe the answer is:
essen
'ruhr location' is the definition.
(city in the Ruhr region of Germany)
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for essen that I've seen before include "Industrial city of northwest Germany" , "city in the Ruhr valley" , "European city" , "German industrial city on the Ruhr" , "Main industrial city of the Ruhr" .)