Assume he's from London (3)
I believe the answer is:
don
'assume' is the definition.
(I know that assume can be written as don)
'he's from london' is the wordplay.
'DON' is hidden within the letters.
However, I'm uncertain how this is indicated.
Can you help me to learn more?
(Other definitions for don that I've seen before include "Put on clothes like noss" , "Put on the learned man" , "University teacher" , "Professor" , "Put on; college teacher" .)