At heart, professional pride the making of these web designers (7)
I believe the answer is:
spiders
'these web designers' is the definition.
'at heart professional pride the making' is the wordplay.
'at' means one lot of letters go next to another.
'heart' indicates the central letters.
'the making' is an anagram indicator.
The middle of 'professional' is 'ss'.
'ss'+'pride' is 'sspride'.
'sspride' is an anagram of 'SPIDERS'.
'of' acts as a link.
(Other definitions for spiders that I've seen before include "Arachnids" , "Insects; rests" , "Web weavers" , "Predators on the web" , "14 [BOWIE] 's band from 26 [MARS]" .)