At home, answer female with whip without hesitation (2,1,5)
I believe the answer is:
in a flash
'without hesitation' is the definition.
(in a flash means immediately)
'at home answer female with whip' is the wordplay.
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'answer' becomes 'a' (abbreviation eg in Q and A).
'female with' becomes 'f' (I've seen this in other clues).
'whip' becomes 'lash' (synonyms).
'in'+'a'+'f'+'lash'='IN A FLASH'
(Other definitions for in a flash that I've seen before include "Where American detected electricity" , "How lightning appears" , "Very quickly" , "Almost instantly" , "Instantly, straightaway" .)