At home, anxious and profound (7)
I believe the answer is:
intense
'profound' is the definition.
(associated in meaning)
'at home anxious' is the wordplay.
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'anxious' becomes 'tense' (I've seen this before).
'in'+'tense'='INTENSE'
'and' acts as a link.
(Other definitions for intense that I've seen before include "'Ardent, forceful (7)'" , "burning" , "Acute, exteme" , "Deeply emotional" , "Showing strong feelings or opinions" .)