At home with single part of shoe (6)
I believe the answer is:
insole
'part of shoe' is the definition.
(I know that insole part of shoe)
'at home with single' is the wordplay.
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'with' says to put letters next to each other.
'single' becomes 'sole' (similar in meaning).
'in'+'sole'='INSOLE'
(Other definitions for insole that I've seen before include "Lesion in part of foot" , "Part of Oxford perhaps" , "Inner part of shoe" , "Part of a shoe or boot" , "support for rambler, perhaps" .)