At the end of one's rope (3,2)
I believe the answer is:
fed up
'at the end of one's rope' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for fed up that I've seen before include "Bored - irritated" , "Bored, finding life tedious" , "far from happy?" , "Depressed" , "Informally bored or discontented (3,2)" .)