At the end of the day, she makes a fresh start! (3)

'a fresh start' is the definition.
Both the answer and definition are singular nouns.
Perhaps there's an association between them I don't understand?

'at the end of the day she' is the wordplay.
'at' is a charade indicator (letters next to each other).
'the end of' says to take the final letters.
'she' becomes 'fa' (I can't explain this - if you can you should believe this answer much more).
The final letter of 'day' is 'y'.
'y' put after 'fa' is 'FAY'.

'makes' is the link.

Can you help me to learn more?