At the outset seemingly anxious for everyone to be secure (4)
I believe the answer is:
safe
'be secure' is the definition.
(associated in meaning)
'at the outset seemingly anxious for everyone' is the wordplay.
'at the outset' suggests taking the first letters.
The initial letters of 'seemingly anxious for everyone' is 'SAFE'.
'to' is the link.
(Other definitions for safe that I've seen before include "Metal box for security" , "Secure - place to keep cash" , "Iron box in which to keep money or important papers" , "Unharmed" , "Free from risk" .)