Aviators, ignoring the odds, race to Saturn in a frenzy (9)
I believe the answer is:
aeronauts
'aviators' is the definition.
('aeronaut' can be a synonym of 'aviator')
'ignoring the odds race to saturn in a frenzy' is the wordplay.
'ignoring the odds' indicates alternate letters (letters in odd-numbered positions are removed).
'in a frenzy' indicates an anagram.
'race'+'to'='raceto'
The alternating letters of 'raceto' are 'aeo'.
'aeo'+'saturn'='aeosaturn'
'aeosaturn' is an anagram of 'AERONAUTS'.
(Another definition for aeronauts that I've seen is " Balloonists or airmen".)