Avoid first female commercial break (5)
I believe the answer is:
evade
'avoid' is the definition.
(I know that avoid is a is a more specific form of the action of evade)
'female commercial break' is the wordplay.
'female' becomes 'eve' (Eve is an example).
'commercial' becomes 'ad' (abbreviation for advertisement).
'break' means one lot of letters goes inside another (inserted letters break the word apart).
'eve' enclosing 'ad' is 'EVADE'.
'first' acts as a link.
(Other definitions for evade that I've seen before include "Dodge, elude" , "Dodge, keep clear of" , "Dodge (taxes)" , "To get away from" , "Manage to avoid" .)