Avoid First Lady touring area with diamonds (5)
I believe the answer is:
evade
'avoid' is the definition.
(evading is a kind of avoiding)
'first lady touring area with diamonds' is the wordplay.
'first lady' becomes 'eve' (I've seen this before**).
'touring' indicates putting letters inside (touring can mean going round).
'area' becomes 'a' (maths abbreviation).
'with' means one lot of letters go next to another.
'diamonds' becomes 'd' (abbreviation in bridge say).
'a'+'d'='ad'
'eve' going around 'ad' is 'EVADE'.
(Other definitions for evade that I've seen before include "Escape (something)" , "Artfully dodge" , "Avoid, get out of" , "Dodge by cleverness or trickery" , "avoid answering" .)