Awfully nice in South Carolina, picturesque (6)
I believe the answer is:
scenic
'picturesque' is the definition.
(I've seen this before)
'awfully nice in south carolina' is the wordplay.
'awfully' indicates an anagram.
'in' means one lot of letters goes inside another.
'south carolina' becomes 'sc'.
'nice' with letters rearranged gives 'ceni'.
'ceni' going into 'sc' is 'SCENIC'.
(Other definitions for scenic that I've seen before include "Of route, having pleasent views" , "This route has pleasing vistas" , "Offering landscape views" , "Picturesque, beautiful" , "Relating to picturesque countryside" .)