Awkward first drug dispute (6)
I believe the answer is:
strife
'dispute' is the definition.
(thesaurus)
'awkward first drug' is the wordplay.
'awkward' indicates anagramming the letters.
'drug' becomes 'e' (e is another name for ecstasy).
'first' anagrammed gives 'strif'.
'strif'+'e'='STRIFE'
(Other definitions for strife that I've seen before include "Warfare" , "Conflict, quarrelling" , "'Discord, conflict (6)'" , "Refits (anag)" , "A Cockney's wife is his trouble and .....(60" .)