Awkwardly hustle Holmes for one (6)
I believe the answer is:
sleuth
'holmes for one' is the definition.
(Sherlock Holmes is an example)
'awkwardly hustle' is the wordplay.
'awkwardly' indicates anagramming the letters.
'hustle' with letters rearranged gives 'SLEUTH'.
(Other definitions for sleuth that I've seen before include "Hustle (anag)" , "Hustle for a clever detective like Sherlock" , "Investigator (informal)" , "Gumshoe" , "Detective; play and film" .)