Ban leads, ores, uranium, titanium with legislation (6)
I believe the answer is:
outlaw
'ban' is the definition.
(I've seen this in another clue)
'leads ores uranium titanium with legislation' is the wordplay.
'leads' suggests taking the first letters (I've seen 'leading' mean this).
'with' means one lot of letters go next to another.
'legislation' becomes 'law' (I've seen this in other clues).
The first letters of 'ores uranium titanium' is 'out'.
'out'+'law'='OUTLAW'
(Other definitions for outlaw that I've seen before include "Wanted criminal" , "Embargo" , "Robin Hood, for example" , "He broke the rules in the old West" , "Ban, make illegal" .)