Barmy old eccentric in Italian region (8)
I believe the answer is:
lombardy
'italian region' is the definition.
(Lombardy is an example)
'barmy old eccentric' is the wordplay.
'eccentric' is an anagram indicator.
'barmy'+'old'='barmyold'
'barmyold' is an anagram of 'LOMBARDY'.
'in' is the link.
(Other definitions for lombardy that I've seen before include "Region of northern Italy" , "Region around Milan" , "Great Italian plain between Alps and Po" , "somewhere in Italy" , "Italian region between Alps and the river Po" .)