Bart's sis (4)

I believe the answer is:

lisa

(Other definitions for lisa that I've seen before include "Mona . . . ., famous painting by Leonardo da Vinci" , "Girl" , "Leonardo da Vinci painted the 'Mona ....'" , "Most intelligent of Marge Simpson's children" , "Mona ..., also called La Gioconda" .)

I've seen this clue in the Penny Press and the King Feature Syndicate.

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