Be hopeless at naming twins (7)
I believe the answer is:
despair
'be hopeless' is the definition.
(I've seen this before)
'naming twins' is the wordplay.
'naming' becomes 'des' (I am not sure about this - if you are sure you should believe this answer much more).
'twins' becomes 'pair' (a pair of twins).
'des'+'pair'='DESPAIR'
'at' acts as a link.
Can you help me to learn more?
(Other definitions for despair that I've seen before include "Misery" , "Complete loss of hope" , "Opposite of 10" , "Resignation" , "Abandon hope" .)