Be upstanding? Wrong (4)
I believe the answer is:
evil
'wrong' is the definition.
(associated in meaning)
'be upstanding?' is the wordplay.
'be' becomes 'live' (living is a kind of being).
'upstanding?' is a reversal indicator (I've seen 'upstanding' mean this).
'live' reversed gives 'EVIL'.
(Other definitions for evil that I've seen before include "Great wickedness" , "Morally objectionable behavior" , "Extremely bad" , "Live badly in depravity" , "heinous" .)