Be without hope (7)
I believe the answer is:
despair
'be without hope' is the definition.
(I've seen this before)
This is all the clue.
(Other definitions for despair that I've seen before include "Lose heart" , "The feeling that nothing will turn out well" , "Feeling of hopelessness" , "A spider (anag.)" , "Praised (anag) - lose hope" .)