Become very angry and look ready to get hold of me (4,2)
I believe the answer is:
lose it
'become very angry' is the definition.
(to lose it is to suddenly become very angry)
'look ready to get hold of me' is the wordplay.
'look' becomes 'lo' (archaic term meaning 'look!').
'ready' becomes 'set' (similar in meaning).
'to get hold of' means one lot of letters goes inside another.
'me' becomes 'I'.
'set' going around 'i' is 'seit'.
'lo'+'seit'='LOSE IT'
'and' is the link.
(Other definitions for lose it that I've seen before include "Snap" , "Suddenly go berserk" .)