Beer makes one resentful (6)
I believe the answer is:
bitter
I believe this is a double definition.
'beer' is the first definition.
(I've seen this before)
'one resentful' is the second definition.
(thesaurus)
'makes' is the link.
(Other definitions for bitter that I've seen before include "Sour British beer?" , "drink" , "Sour tasting, like English ale" , "Resentful, being piercingly cold" , "Having a sharp, acid taste" .)