Before a possible setback (3)
I believe the answer is:
ere
'before' is the definition.
(usually literary)
I can't explain the rest of the clue.
Can you help me to learn more?
(Other definitions for ere that I've seen before include "Before (literary)" , "Old word for before" , "One who steals" , "Archaic word for before - a palindrome" , "Before (in time)" .)