Before end of symphony, loser turns up gripping instrument with determination (10)
I believe the answer is:
resolutely
'with determination' is the definition.
Both the answer and definition are adverbs. Perhaps you can see an association between them that I can't see?
'before end of symphony loser turns up gripping instrument' is the wordplay.
'before' is a charade indicator (letters next to each other).
'end of' says to take the final letters.
'turns up' says the letters should be written in reverse.
'gripping' is an insertion indicator (inserted letters are gripped).
'instrument' becomes 'lute' (lute is a kind of instrument).
The last letter of 'symphony' is 'y'.
'loser' written backwards gives 'resol'.
'resol' going around 'lute' is 'resolutel'.
'y' put after 'resolutel' is 'RESOLUTELY'.
Can you help me to learn more?
(Another definition for resolutely that I've seen is " without a doubt".)