Begin with Frank (4)
I believe the answer is:
open
I believe this clue is a double definition.
'begin' is the first definition.
(opening is a kind of begining)
'frank' is the second definition.
('open' can be a synonym of 'frank')
'with' is the link.
(Other definitions for open that I've seen before include "Frank; unobstructed" , "gaping" , "Golf tournament" , "Exposed to the air" , "Liberal" .)