Behold saints making sacrifice? (4)
I believe the answer is:
loss
'sacrifice?' is the definition.
(thesaurus)
'behold saints' is the wordplay.
'behold' becomes 'lo'.
'saints' becomes 'ss'.
'lo'+'ss'='LOSS'
'making' is the link.
(Other definitions for loss that I've seen before include "(Sports) defeat" , "Deficit" , "Red figures on a balance sheet or ledger" , "Defeat; bereavement" , "Defeat (in sport)" .)