Beset with bad luck, Jack isn't regularly cross with Edward (6)
I believe the answer is:
jinxed
'beset with bad luck' is the definition.
(I've seen this before)
'jack isn't regularly cross with edward' is the wordplay.
'jack' becomes 'J' (playing card abbreviation).
'regularly' means one should take alternating letters (regularly take one letter, leave next etc.).
'cross' becomes 'x' (X is cross-shaped).
'with' means one lot of letters go next to another.
'edward' becomes 'ed'.
The alternate letters of 'isnt' are 'in'.
'j'+'in'+'x'+'ed'='JINXED'
(Other definitions for jinxed that I've seen before include "Marked by regular bad luck" , "Beset with bad luck" , "Unlucky" , "Cursed" , "Subjected to bad luck" .)