Biased octet in wedlock? (8)
I believe the answer is:
weighted
'biased' is the definition.
(as in a biased or weighted sample)
'octet in wedlock?' is the wordplay.
'octet' becomes 'eight' (synonyms).
'in' indicates putting letters inside.
'wedlock?' becomes 'wed' (I can't justify this - if you can you should give a lot more credence to this answer).
'eight' inserted into 'wed' is 'WEIGHTED'.
Can you help me to learn more?
(Other definitions for weighted that I've seen before include "loaded" , "Made heavier" , "Given a bias" , "having extra burden to carry" .)