Big ___ , German siege howitzer built by Krupp and used by the German army in WWI (6)
I believe the answer is:
bertha
(Other definitions for bertha that I've seen before include "Girl's name - big German WWI gun" , "Female name; Big -, World War one German howitzer" , "Breath (anag) - girl's name" , "big woman?" , "43-ton German howitzer, Big _____" .)