Big guns in article, Times story (3,5,6)
I believe the answer is:
the great gatsby
'story' is the definition.
(F Scott Fitzgerald novel)
'big guns in article times' is the wordplay.
'big' becomes 'great' ('great' can be similar in meaning to 'big').
'guns' becomes 'gats' (gat is a kind of gun).
'in' means one lot of letters goes inside another.
'article times' becomes 'theby' (I can't justify this - if you can you should believe this answer much more).
'great'+'gats'='greatgats'
'greatgats' inserted within 'theby' is 'THE GREAT GATSBY'.
(Other definitions for the great gatsby that I've seen before include "Book" , "classic work" , "F Scott Fitzgerald novel" .)