Big hit - 150 published (5)
I believe the answer is:
clout
'big hit' is the definition.
'clout' can be an answer for 'hit' (I've seen this before). I am not sure about the 'big' bit.
'150 published' is the wordplay.
'150' becomes 'CL' (Roman numerals).
'published' becomes 'out' (I've seen this in another clue).
'cl'+'out'='CLOUT'
Can you help me to learn more?
(Other definitions for clout that I've seen before include "Cuff" , "Punch; influence" , "Swipe" , "Influence or power" , "Influence; heavy blow" .)