Big shot?
'big shot' is the definition.
(thesaurus)
This is the entire clue.
(Other definitions for vip that I've seen before include "Important individual, initially" , "'High-ranking person, initially (3)'" , "Significant or high-ranking person, in short" , "Initially, individual of high status and influence" , "The red carpet is rolled out for him" .)
(Other definitions for vaccine that I've seen before include "Preparation for inoculations" , "Antibody stimulator" , "Immunity provider" , "Vice can create protection against disease" , "Antigenic preparation" .)