Big toe woe (6)
I believe the answer is:
bunion
'big toe woe' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for bunion that I've seen before include "Painful swelling at base of big toe" , "Swelling at base of toe with thickened skin" , "Something painful" , "Foot fault" , "Painful swelling of the big toe joint" .)