Bill? He is hurt (4)
I believe the answer is:
ache
'is hurt' is the definition.
(I've seen this before)
'bill? he' is the wordplay.
'bill?' becomes 'ac' (short for account).
'ac'+'he'='ACHE'
(Other definitions for ache that I've seen before include "Feel sore" , "Persistent dull pain" , "Cause pain" , "Hanker" , "Play up" .)