Crossword Genius

Bitterness

Ross

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(Other definitions for bile that I've seen before include "Anger, bitterness" , "Ill-temper" , "Gall bladder substance" , "Bitterness - digestive fluid stored in the gall bladder" , "Irritability, bad temper" .)

I've seen this clue in The Independent, The Mirror and The Telegraph.
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