Bless a number at home time (6)
I believe the answer is:
anoint
'bless' is the definition.
(anointing is a kind of blessing)
'a number at home time' is the wordplay.
'number' becomes 'no' (abbreviation).
'at home' becomes 'in' ('I'm in' can mean 'I'm at home').
'time' becomes 't' (abbreviation).
'a'+'no'+'in'+'t'='ANOINT'
(Other definitions for anoint that I've seen before include "Administer sacred oils as to the sick" , "Bless with sacred oils" , "Apply oil as sign of consecration" , "Consecrate with oil or ointment" , "Bless with holy oil" .)