Blobby, single-celled organism (6)
![Ross](/clue/static/ross-mug.min.png)
I believe the answer is:
amoeba
(Other definitions for amoeba that I've seen before include "little creature" , "Microscopic organism of single cell that changes shape constantly" , "One-celled animal found in water" , "Protozoan of ever-changing shape" , "Tiny organism consisting of single changing cell" .)