Blockbusters taking prime slots in this TV show (4)
I believe the answer is:
hits
'blockbusters' is the definition.
(blockbuster can mean a commercial hit)
'prime slots in this tv show' is the wordplay.
'this' can be anagrammed to 'HITS'.
However, I am unsure how the anagram is indicated.
'taking' acts as a link.
(Other definitions for hits that I've seen before include "that please the public?" , "Raps - successful recordings" , "The sort of strikes" , "welcome in the theatre world?" , "Top pops" .)