Bloke's beginning to run — body part sending message? (7)
I believe the answer is:
bladder
'body part sending message?' is the definition.
(the bladder messages the brain)
'bloke's beginning to run' is the wordplay.
'beginning to' indicates taking the first letters.
'run' becomes 'ladder' (both can mean a rip in tights).
The first letter of 'blokes' is 'b'.
'b'+'ladder'='BLADDER'
(Other definitions for bladder that I've seen before include "Chamber" , "organ" , "Distensible bag" , "Bag containing liquid or gas" , "Bag in the lower abdomen" .)