Blood of the gods upsets the choir (5)
I believe the answer is:
ichor
'blood of the gods' is the definition.
(I've seen this before)
'upsets the choir' is the wordplay.
'upsets' is an anagram indicator.
'choir' is an anagram of 'ICHOR'.
(Other definitions for ichor that I've seen before include "Choir (anag.); gods' life force" , "Fluid in divine veins" , "Blood-fluid of the gods" , "divine juice" , "divine stuff" .)