Blood shot again (4)
I believe the answer is:
gore
'blood' is the definition.
('gore' can be a synonym of 'blood')
'shot again' is the wordplay.
'shot' becomes 'go' (I've seen this in other clues).
'again' becomes 're'.
'go'+'re'='GORE'
(Other definitions for gore that I've seen before include "Impale" , "Pierce with horn - blood" , "Blood that's been shed" , "stuff from part of Kensington" , "Make a hole in" .)