Blow chances finally getting question with queen (8)
I believe the answer is:
squander
'blow' is the definition.
(synonyms)
'chances finally getting question with queen' is the wordplay.
'finally' indicates one should take the final letters.
'getting' is a charade indicator (letters next to each other).
'question' becomes 'qu'.
'with' becomes 'and'.
'queen' becomes 'ER' (abbreviation for Elizabeth Regina).
The final letter of 'chances' is 's'.
's'+'qu'+'and'+'er'='SQUANDER'
(Other definitions for squander that I've seen before include "Waste (a resource) recklessly" , "blow" , "Use up wastefully" , "Fritter away, waste" , "Dissipate" .)