Bonier pale bits, not open to surgery (10)
I believe the answer is:
inoperable
'bits not open to surgery' is the definition.
I can't tell whether this definition defines the answer.
'bonier pale' is the wordplay.
'bonier pale' can be anagrammed to 'INOPERABLE'.
But, I'm unsure how the anagram is indicated.
Can you help me to learn more?
(Other definitions for inoperable that I've seen before include "Incapable of being made to work" , "Not curable by surgery" .)