Book about blind man, very much missed by son (5)
I believe the answer is:
tobit
'book about blind man' is the definition.
(Book of Tobit, apocryphal book of the Bible)
'very much missed by son' is the wordplay.
'very much' becomes 'to bits' (eg loving someone to bits is loving them very much).
'missed by' suggests deleting specific letters.
'son' becomes 's' (genealogical abbreviation for son).
'tobits' with 's' taken out is 'TOBIT'.
(Other definitions for tobit that I've seen before include "apocryphal book" , "Old Testament character" , "Book of the Apocrypha" , "Good book" .)