Boredom from these craven nuisances (5)
I believe the answer is:
ennui
'boredom' is the definition.
(synonyms)
'from these craven nuisances' is the wordplay.
'from' indicates a hidden word.
'ENNUI' can be found hidden inside 'these craven nuisances'.
(Other definitions for ennui that I've seen before include "Effect of boredom" , "doldrums" , "Feeling of weariness or boredom" , "Result of boredom" , "Feeling of dissatisfaction" .)