Bosses ignoring Republican blunders (6)
I believe the answer is:
gaffes
'blunders' is the definition.
(gaffe is a kind of blunder)
'bosses ignoring republican' is the wordplay.
'bosses' becomes 'gaffers' ('gaffer' can be a synonym of 'boss').
'ignoring' is a deletion indicator.
'republican' becomes 'r' (abbreviation).
'gaffers' with 'r' removed is 'GAFFES'.
(Other definitions for gaffes that I've seen before include "Faux pas" , "Socially embarrassing actions or remarks" , "bloomers" , "Social blunders, often of speech" , "Embarrassing blunders" .)